HRID890495

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11776

Triphenylphosphine

C18H15P

HCID97268

Di-tert-butyl azodicarboxylate

C10H18N2O4

结构：OCCc1cnc(-c2ccc(C(F)(F)F)cc2)nc1C1CC1

HCID22250819

未命名化合物

HCID68821422

(6-Hydroxy-indol-1-yl)-acetic acid ethyl ester

C12H13NO3

PRODUCTS

生成物

结构：CCOC(=O)Cn1ccc2ccc(OCCc3cnc(-c4ccc(C(F)(F)F)cc4)nc3C3CC3)cc21

HCID69641848

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

In analogy to the procedure described in example 5 f], (6-hydroxy-indol-1-yl)-acetic acid ethyl ester (example 6 b]) was reacted with 2-[4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-ethanol in the presence of di-tert-butyl azodicarboxylate and triphenylphosphine in tetrahydrofuran to yield the title compound as colorless liquid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3c29a3008d9b4614a95beb4bf170310a
来源数据集: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06995263B2
来源说明: uspto-grants-2006_02

反应 SMILES

[CH2:1]([O:3][C:4](=[O:16])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([OH:15])[CH:13]=2)[CH:8]=[CH:7]1)[CH3:2].[CH:17]1([C:20]2[C:25]([CH2:26][CH2:27]O)=[CH:24][N:23]=[C:22]([C:29]3[CH:34]=[CH:33][C:32]([C:35]([F:38])([F:37])[F:36])=[CH:31][CH:30]=3)[N:21]=2)[CH2:19][CH2:18]1.N(C(OC(C)(C)C)=O)=NC(OC(C)(C)C)=O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>O1CCCC1>[CH2:1]([O:3][C:4](=[O:16])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH2:27][CH2:26][C:25]3[C:20]([CH:17]4[CH2:19][CH2:18]4)=[N:21][C:22]([C:29]4[CH:34]=[CH:33][C:32]([C:35]([F:38])([F:36])[F:37])=[CH:31][CH:30]=4)=[N:23][CH:24]=3)[CH:13]=2)[CH:8]=[CH:7]1)[CH3:2]