反应详情

To a solution of 1.90 g (6.9 mmol) 1-[2-(4-all yloxy-benzylsulfanyl)-ethyl]-1H-[1,2,3]triazole in 150 ml dichloromethane was added dropwise at −30° C. a solution of 1.86 g (8.3 mmol) 3-chloro-benzenecarboperoxoic acid in 40 ml ethyl acetate and stirring continued for 1 hour. The mixture was allowed to warm up over night, washed with sodium bicarbonate and sodium carbonate solution, then with water, dried and evaporated. Elution form silica with ethyl acetate/methanol 5:1 furnished 1.25 g (62%) 1-[2-(4-allyloxy-phenylmethanesulfinyl)-ethyl]-1H-[1,2,3]triazole as white solid.

1. temperatureto warm up over night
2. washwashed with sodium bicarbonate and sodium carbonate solution
3. dry with materialwith water, dried
4. customevaporated
5. washElution
6. customform silica with ethyl acetate/methanol 5:1