反应详情

20 ml of pyridine was added to 5.02 g (49.2 mM) of n-hexanol, followed by stirring below 0° C. To the mixture, 11.24 g (59.0 mM) of p-toluenesulfonyl chloride was added. The mixture was stirred for 6 hours below 0° C. After the reaction, the reaction mixture was poured into iced water and acidified with conc. HCl, followed by two times of extraction with dichloromethane, two times of washing with water, drying with sodium sulfate and distilling-off of the solvent to obtain 12.0 g (46.8 mM) of an objective product (yield: 95.0%).

1. stirringThe mixture was stirred for 6 hours below 0° C
2. customAfter the reaction
3. extractionfollowed by two times of extraction with dichloromethane, two times
4. washof washing with water
5. dry with materialdrying with sodium sulfate and distilling-off of the solvent