Triethylamine → HCID 19096826, compound

HRID 893196Notes

Reaction equation

HRID 893196 reaction equation
Cl[C:2]([C:4]1([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:8][CH2:7][CH2:6][CH2:5]1)=[O:3].[Br:14][C:15]1[CH:21]=[CH:20][C:18]([NH2:19])=[C:17]([CH3:22])[CH:16]=1.C(N(CC)CC)C>O1CCCC1>[Br:14][C:15]1[CH:21]=[CH:20][C:18]([NH:19][C:2]([C:4]2([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:8][CH2:7][CH2:6][CH2:5]2)=[O:3])=[C:17]([CH3:22])[CH:16]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 114234-Bromo-2-methylanilineHCID 19096799Ethyl 1-(chlorocarbonyl)cyclopentane-1-carboxylate

Product 1

HCID 19096826HCID 19096826, compoundYield 35%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ethyl 1-chlorocarbonylcyclopentanecarboxylate (3.10 grams, 0.02 mole) prepared in Example XX, 4-bromo-2-methylaniline (2.82 grams, 0.02 mole) and triethylamine (1.53 grams, 0.02 mole) were reacted in tetrahydrofuran (200 milliliters) under conditions similar to those described in Example I to give 2.40 grams (0.007 mole) of ethyl 1-(4-bromo-2-methylphenylaminocarbonyl)cyclopentanecarboxylate which, after recrystallization from hexane, had a melting point of 64° C.-67° C.

Sources & evidence

ORD record
ord-5c4b8dd403874011b3ee3510f3fea649
Source dataset
uspto-grants-1992_06
Patent number
US05123951

Reaction notes

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