Pyridine-2-carbonitrile → 4-(4-Hydroxy-5-phenyl-2-thiazolyl)benzoic acid

HRID 893336Notes

Reaction equation

HRID 893336 reaction equation
[C:1]([OH:11])(=S)[CH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)O.[C:12]([C:14]1[CH:22]=[CH:21][C:17]([C:18]([OH:20])=[O:19])=[CH:16][CH:15]=1)#[N:13].C(O)(=[S:27])C(C)O.C(C1C=CC=CN=1)#N>>[C:18]([C:17]1[CH:21]=[CH:22][C:14]([C:12]2[S:27][C:2]([C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=3)=[C:1]([OH:11])[N:13]=2)=[CH:15][CH:16]=1)([OH:20])=[O:19]

Participants

5

Reactant 4

HCID 7522Pyridine-2-carbonitrileHCID 120874-Cyanobenzoic acidHCID 178473673HCID 178473673, compoundHCID 1785262032-hydroxy-2-phenylethanethioic S-acid

Product 1

HCID 156918174-(4-Hydroxy-5-phenyl-2-thiazolyl)benzoic acid

Procedure

The title compound was prepared according to the method of Scheme I in a manner analogous to Example 1 except thiomandelic acid and 4-cyanobenzoic acid were used instead of thiolactic acid and 2-cyanopyridine respectively.

Sources & evidence

ORD record
ord-51c392074874456cad957fd0ff50ce44
Source dataset
uspto-grants-1992_06
Patent number
US05124342

Reaction notes

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