Hydrochloric Acid → HCID 15341831, compound

HRID 893471Notes

Reaction equation

HRID 893471 reaction equation
[CH3:1][O:2][C:3]1[C:4]([CH2:34][CH:35]=[CH2:36])=[C:5]([CH:27]=[CH:28][C:29]=1[C:30]([NH:32][CH3:33])=[O:31])[O:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[C:12]([CH2:24][CH2:25][CH3:26])=[C:13]([CH:21]=[CH:22][CH:23]=1)[O:14][CH2:15][C:16]([O:18]CC)=[O:17].[OH-].[Li+].CO.Cl>O>[CH3:1][O:2][C:3]1[C:4]([CH2:34][CH:35]=[CH2:36])=[C:5]([CH:27]=[CH:28][C:29]=1[C:30]([NH:32][CH3:33])=[O:31])[O:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[C:12]([CH2:24][CH2:25][CH3:26])=[C:13]([CH:21]=[CH:22][CH:23]=1)[O:14][CH2:15][C:16]([OH:18])=[O:17]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3939Lithium HydroxideHCID 15341830HCID 15341830, compound

Product 1

HCID 15341831HCID 15341831, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The compound of Example 52 (95 mg, 0.19 mmol) and 380 μl (0.38 mmol) of 1 M lithium hydroxide were added to 2.0 ml of methanol, and the reaction mixture was stirred for four hours at room temperature. The solvent was removed under vacuum to give a white solid which was suspended in 5.0 ml of water. The mixture was acidified with 10% hydrochloric acid, stirred and filtered to remove the resultant solid which was then dried at 40° C. overnight in a vacuum oven to give the product.

Workup

  1. customThe solvent was removed under vacuum
  2. customto give a white solid which
  3. stirringstirred
  4. filtrationfiltered
  5. customto remove the resultant solid which
  6. customwas then dried at 40° C. overnight in a vacuum oven
  7. customto give the product

Sources & evidence

ORD record
ord-15da0889880c46cc98e017dab9d4e919
Source dataset
uspto-grants-1992_06
Patent number
US05124350

Reaction notes

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