Trifluoroacetic acid → HCID 131717438, compound

HRID 893756Notes

Reaction equation

HRID 893756 reaction equation
[I-].C(OC([NH:9][CH:10]1[C:54](=[O:55])[N:12]2[C:13]([C:38]([O:40]C(C3C=CC=CC=3)C3C=CC=CC=3)=[O:39])=[C:14](/[CH:17]=[CH:18]/[CH2:19][N+:20]3([CH3:37])[CH2:28][C:27]4[C:22](=[CH:23][C:24]([O:33][C:34](=[O:36])[CH3:35])=[C:25]([O:29][C:30](=[O:32])[CH3:31])[CH:26]=4)[CH2:21]3)[CH2:15][S:16][C@H:11]12)=O)(C)(C)C.[C:56]([OH:62])([C:58]([F:61])([F:60])[F:59])=[O:57]>C(OC(C)C)(C)C>[F:59][C:58]([F:61])([F:60])[C:56]([O-:62])=[O:57].[NH2:9][CH:10]1[C:54](=[O:55])[N:12]2[C:13]([C:38]([OH:40])=[O:39])=[C:14](/[CH:17]=[CH:18]/[CH2:19][N+:20]3([CH3:37])[CH2:28][C:27]4[C:22](=[CH:23][C:24]([O:33][C:34](=[O:36])[CH3:35])=[C:25]([O:29][C:30](=[O:32])[CH3:31])[CH:26]=4)[CH2:21]3)[CH2:15][S:16][C@H:11]12

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131717440HCID 131717440, compound

Product 1

HCID 131717438HCID 131717438, compound

Reagents, catalysts & solvents 1

HCID 7914Diisopropyl EtherSolvent

Procedure

Diphenylmethyl 7-t-butoxycarbonylamino-3-[(E)-3-(5,6-diacetoxy-2-methyl-2-isoindolinio)-1-propen-1-yl]-3-cephem-4-carboxylate iodide (Va) (610 mg, 0.69 mmol) was treated with TFA (6 ml) at room temperature for 30 min. The reaction mixture was diluted with isopropyl ether. The resulting precipitate was collected by filtration to yield 502 mg (quantitative yield) of the title compound.

Workup

  1. filtrationThe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-5942ceb183e44d2aaedab5f8ac49fb5e
Source dataset
uspto-grants-1992_06
Patent number
US05126336

Reaction notes

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