Sodium hydride → HCID 12800082, compound

HRID 893870Notes

Reaction equation

HRID 893870 reaction equation
[CH3:1][C:2]1[N:3]([NH:8][C:9](=[O:12])[CH2:10][Cl:11])[C:4]([CH3:7])=[CH:5][CH:6]=1.[CH3:13][C:14]1[S:15][CH:16]=[C:17]([CH2:19]Cl)[N:18]=1.[H-].[Na+]>CN(C=O)C>[CH3:13][C:14]1[S:15][CH:16]=[C:17]([CH2:19][N:8]([N:3]2[C:2]([CH3:1])=[CH:6][CH:5]=[C:4]2[CH3:7])[C:9](=[O:12])[CH2:10][Cl:11])[N:18]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 7363414-(Chloromethyl)-2-methyl-1,3-thiazoleHCID 12800072HCID 12800072, compound

Product 1

HCID 12800082HCID 12800082, compoundYield 20.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The product of Example 2 (5.04 g), 2-methyl-4-chloromethyl-1,3-thiazole (4 g) and sodium hydride (1.56 g) in 120 ml dry DMF were treated at 0° C. according to the procedure of Example 3. Work-up yielded 1.67 g of title product (chromatographed on silica gel and by h.p.l.c.).

Sources & evidence

ORD record
ord-a8ecc7cdfe9a46789dcbf9ea5bef30b6
Source dataset
uspto-grants-1981_08
Patent number
US04282028

Reaction notes

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