Diethyl Succinate → HCID 20532902, compound

HRID 894301Notes

Reaction equation

HRID 894301 reaction equation
[C:1]([O:10][CH2:11][CH3:12])(=[O:9])[CH2:2][CH2:3][C:4]([O:6]CC)=O.[CH3:13][C:14]1[CH:22]=[C:21]([CH3:23])[CH:20]=[CH:19][C:15]=1[CH2:16][C:17]#[N:18].[Na]>C(O)C>[CH3:13][C:14]1[CH:22]=[C:21]([CH3:23])[CH:20]=[CH:19][C:15]=1[CH:16]([C:17]#[N:18])[C:4](=[O:6])[CH2:3][CH2:2][C:1]([O:10][CH2:11][CH3:12])=[O:9]

Participants

5

Reactant 3

HCID 31249Diethyl SuccinateHCID 1443032,4-DimethylphenylacetonitrileHCID 5360545Sodium

Product 1

HCID 20532902HCID 20532902, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This material was prepared using 130.65 g (0.750 mol) of diethyl succinate, 72.60 g (0.500 mol of 2,4-dimethylbenzyl cyanide, 14.95 g (0.65 mol) of sodium, and 168 ml of dry ethanol using the procedure described in Part A of Example I. The product was obtained as a dark red oil, 106.5 g (78% yield).

Workup

  1. customThis material was prepared
  2. customThe product was obtained as a dark red oil, 106.5 g (78% yield)

Sources & evidence

ORD record
ord-16fea77b96534d6fa4e6d733ef0c69b3
Source dataset
uspto-grants-1981_08
Patent number
US04283348

Reaction notes

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