Imidazole → HCID 20550246, compound

HRID 894524Notes

Reaction equation

HRID 894524 reaction equation
[O-]CC.[Na+].[Na].[NH:6]1[CH:10]=[CH:9][N:8]=[CH:7]1.[CH:11]1([CH2:16]Br)[CH2:15][CH2:14][CH2:13][CH2:12]1>C(O)C>[CH:11]1([CH2:16][N:6]2[CH:10]=[CH:9][N:8]=[CH:7]2)[CH2:15][CH2:14][CH2:13][CH2:12]1

Participants

6

Reactant 4

HCID 795ImidazoleHCID 2723922Sodium ethoxideHCID 5360545SodiumHCID 12723264(Bromomethyl)cyclopentane

Product 1

HCID 20550246HCID 20550246, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of sodium ethoxide was made by dissolving sodium (2.3 g, 0.1 mole) in absolute ethanol (100 ml). Imidazole (6.8 g, 0.1 mole) was then added. The mixture was heated under reflux and cyclopentylmethylbromide (16.3 g, 0.1 mole) was added dropwise. The reaction mixture was allowed to reflux for a further 16 hours after addition. The mixture was then left to cool.

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux
  3. temperatureto reflux for a further 16 hours
  4. additionafter addition
  5. waitThe mixture was then left
  6. temperatureto cool

Sources & evidence

ORD record
ord-8a0567d88b034eec907d7d0dd1a22a41
Source dataset
uspto-grants-1981_08
Patent number
US04284641

Reaction notes

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