反应详情

Phosphoryl chloride (0.754 g.) was added dropwise to a solution of N,N-dimethylformamide (0.36 g.) in ethyl acetate (2 ml.) at -10° to -5° C. and stirred at the same temperature for 30 minutes. Ethyl acetate (13 ml.) and 2-(2-formamidothiazol-4-yl)-2-methylthiomethoxyiminoacetic acid (syn isomer, 1.13 g.) were added to the mixture at -10° to 5° C. and stirred at the same temperature for 30 minutes to give an activated acid solution. The solution was added to a solution of 7-amino-3-cephem-4-carboxylic acid (0.82 g.) and bis-(trimethylsilyl)acetamido (4.17 g.) in ethyl acetate (8.2 ml.) at -20° C. and the resulting reaction mixture was stirred at -10° to -5° C. for 30 minutes. After adding water to the resultant solution, the mixture was extracted twice with ethyl acetate. The extracts were washed with a saturated aqueous solution of sodium chloride, dried over magnesium sulfate and concentrated in vacuo. The residue was pulverized with diisopropyl ether, and the precipitates were collected by filtration and dried to give 7-[2-(2-formamidothiazol-4-yl)-2-methylthiomethoxyiminoacetamido]-3-cephem-4-carboxylic acid (syn isomer, 0.26 g.).

1. stirringstirred at the same temperature for 30 minutes
2. customto give an activated acid solution
3. customthe resulting reaction mixture
4. stirringwas stirred at -10° to -5° C. for 30 minutes
5. extractionthe mixture was extracted twice with ethyl acetate
6. washThe extracts were washed with a saturated aqueous solution of sodium chloride
7. dry with materialdried over magnesium sulfate
8. concentrationconcentrated in vacuo
9. filtrationthe precipitates were collected by filtration
10. customdried