反应详情

5,5-Diphenylimidazolidine-2,4-dione (0.5 g) was dissolved in tetrahydrofuran (5 mL), and sodium hydride (60%, in oil) (87 mg) was added at 0° C. under ice-cooling. After stirred for 30 minutes, 2-naphthalenesulfonyl chloride (471 mg) was added at 0° C., and the mixture was stirred at room temperature overnight. After water was added carefully, ethyl acetate (100 mL) was added, and the layers were separated. The resulting organic layer was washed with a saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was distilled off. Further purification by silica gel chromatography (hexane:ethyl acetate=3:1 to 2:1) afforded 320 mg of white powder.

1. temperaturecooling
2. stirringthe mixture was stirred at room temperature overnight
3. customthe layers were separated
4. washThe resulting organic layer was washed with a saturated brine
5. dry with materialdried over anhydrous magnesium sulfate
6. distillationthe solvent was distilled off
7. customFurther purification by silica gel chromatography (hexane:ethyl acetate=3:1 to 2:1)