Hydrochloric Acid → HCID 86067347, compound

HRID 898129Notes

Reaction equation

HRID 898129 reaction equation
C([O:3][CH:4](OCC)[C:5]1[CH:10]=[CH:9][N:8]=[C:7]([S:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[N:6]=1)C.Cl.C([O-])([O-])=O.[Na+].[Na+]>C1COCC1>[CH2:12]([S:11][C:7]1[N:6]=[C:5]([CH:4]=[O:3])[CH:10]=[CH:9][N:8]=1)[CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 69293318HCID 69293318, compound

Product 1

HCID 86067347HCID 86067347, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

4-Diethoxymethyl-2-hexylsulfanyl-pyrimidine (250 mg, 0.8 mmol) was stirred in THF (5 mL) and 4 N HCl (5 mL) at 20° C. for 64 h. The reaction mixture was poured in cold 10% Na2CO3 and extracted twice with AcOEt and once with sat. NaCl solution.

Workup

  1. extractionextracted twice with AcOEt and once with sat. NaCl solution

Sources & evidence

ORD record
ord-040c2d2dd29a436f887b94dba45c3033
Source dataset
uspto-grants-2008_04
Patent number
US07351700B2

Reaction notes

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