反应详情

0.1 Mol of ethyl acetoacetate, 0.1 mol of K2CO3, 0.1 mol of benzyl bromide, 0.01 mmol of PEG-400 (polyethylene glycol 400) and 100 ml of benzene were stirred at 75° C. for 7 hours. After cooling, 20 ml of saturated solution of NH4Cl was added to dissolve solid, and product was extracted with ethyl acetate. After removing the solvent, the residue was distilled under reduced pressure, and a cut fraction was collected at 116-118° C./20 Pa. Yield 74%.

1. temperatureAfter cooling
2. dissolutionto dissolve solid, and product
3. extractionwas extracted with ethyl acetate
4. customAfter removing the solvent
5. distillationthe residue was distilled under reduced pressure
6. customa cut fraction was collected at 116-118° C./20 Pa