HCID 68878264, compound → HCID 59691702, compound

HRID 898562Notes

Reaction equation

HRID 898562 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:16][C:17](=[O:30])[CH2:18][O:19][C:20]2[CH:25]=[CH:24][C:23]([N+:26]([O-])=O)=[CH:22][C:21]=2[Cl:29])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][CH2:10][N:11]([CH2:14][CH3:15])[CH2:12][CH3:13]>CCOC(C)=O.[Pt]>[NH2:26][C:23]1[CH:24]=[CH:25][C:20]([O:19][CH2:18][C:17]([NH:16][C:4]2[CH:5]=[CH:6][C:7]([O:8][CH2:9][CH2:10][N:11]([CH2:14][CH3:15])[CH2:12][CH3:13])=[C:2]([Cl:1])[CH:3]=2)=[O:30])=[C:21]([Cl:29])[CH:22]=1

Participants

4

Reactant 1

HCID 68878264HCID 68878264, compound

Product 1

HCID 59691702HCID 59691702, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

0.310 g (0.679 mmol) of N-[3-chloro-4-(2-diethylamino-ethoxy)-phenyl]-2-(2-chloro-4-nitro-phenoxy)-acetamide (from Example 66) was dissolved in 10.0 mL of EtOAc. After the addition of 0.030 g Pt/C (5%) the mixture was hydrogenated at RT under 15 psi H2 atmosphere for 5 hours. The reaction mixture was filtered and the filtrate was evaporated down i. vac. The residue was dissolved with a little EtOH. The precipitate formed was filtered off and dried i. vac.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customthe filtrate was evaporated down i
  3. dissolutionThe residue was dissolved with a little EtOH
  4. customThe precipitate formed
  5. filtrationwas filtered off
  6. customdried i

Sources & evidence

ORD record
ord-e7499931d93e48c3a2712b011379efb6
Source dataset
uspto-grants-2008_04
Patent number
US07351719B2

Reaction notes

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