反应详情

203 mg (1.236 mmol) of CDT in 4 mL DMF was added to a solution of 345 mg (1.236 mmol) of 3-chloro-4-(2-diethylamino-ethoxy)-phenylamine-hydrochloride (intermediate product Z1b) and 0.56 mL (4.000 mmol) of triethylamine in 40 mL THF and the mixture was stirred for 2 hours at RT. 176 mg (1.236 mmol) of 2,4-dichloro-benzylamine was added, the reaction mixture was refluxed for 4 hours and then evaporated down i. vac. The residue was purified by column chromatography (silica gel, dichloromethane/MeOH/conc. aqueous ammonia 80:20:1) and the product was triturated with diisopropylether.

1. temperaturethe reaction mixture was refluxed for 4 hours
2. customevaporated down i
3. customThe residue was purified by column chromatography (silica gel, dichloromethane/MeOH/conc. aqueous ammonia 80:20:1)
4. customthe product was triturated with diisopropylether