反应详情

A solution of 0.544 g (2.103 mmol) (E)-3-(4′-chloro-biphenyl-4-yl)-acrylic acid, 0.440 g (2.313 mmol) 4-piperidin-1-ylmethyl-phenylamine, 0.736 g (2.313 mmol) TBTU, 0.313 g (2.313 mmol) HOBt and 1.025 mL (7.361 mmol) triethylamine in 10 mL DMF was stirred for 3 h at RT and then poured onto ice water and a little EtOAc. The precipitate was filtered off, washed with water and dried at 80° C. i. vac.

1. additionpoured onto ice water
2. filtrationThe precipitate was filtered off
3. washwashed with water
4. customdried at 80° C. i