Hydrochloric Acid → HCID 11455961, compound

HRID 902253Notes

Reaction equation

HRID 902253 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]([C:16]2([OH:22])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[CH2:9][N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:5]=[CH:6][CH:7]=1.[O:23]([C:30]1[CH:31]=[C:32]([CH:35]=[CH:36][CH:37]=1)[CH:33]=O)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.[ClH:38]>>[ClH:1].[ClH:38].[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]([C:16]2([OH:22])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]2)[CH2:9][N:10]2[CH2:15][CH2:14][N:13]([CH2:33][C:32]3[CH:35]=[CH:36][CH:37]=[C:30]([O:23][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH:31]=3)[CH2:12][CH2:11]2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 382843-PhenoxybenzaldehydeHCID 103815021-[1-(3-Chlorophenyl)-2-piperazin-1-ylethyl]cyclohexanol

Product 1

HCID 11455961HCID 11455961, compound

Procedure

In an analogous manner to Example 117, 1-{1-(3-chlorophenyl)-2-[4-(3-phenoxnbenzyl)piperazin-1-yl]ethyl}cyclohexanol dihydrochloride was prepared from 1-[1-(3-chlorophenyl)-2-piperazin-1-ylethyl]cyclohexanol (see Example 1) and 3-phenoxybenzaldehyde. MS (ESI) m/z 505/507 ([M+H]+); HRMS: calcd for C31H37ClN2O2. 2.00 HCl, 576.2077; found (ESI_FT), 505.26266.

Sources & evidence

ORD record
ord-4e76740137d040b6a988ade633a1a0a0
Source dataset
uspto-grants-2008_04
Patent number
US07365076B2

Reaction notes

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