Ethyl formate → Ethyl 3-(5,6-dimethyl-3-pyridyl)-2-formylpropionate

HRID 903347Notes

Reaction equation

HRID 903347 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:5]=[N:6][C:7]=1[CH3:8].[CH:16](OCC)=[O:17].[H-].[Na+]>C(COC)OC>[CH3:1][C:2]1[CH:3]=[C:4]([CH2:9][CH:10]([CH:16]=[O:17])[C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:5]=[N:6][C:7]=1[CH3:8]

Participants

5

Reactant 3

HCID 8025Ethyl formateHCID 24758Sodium hydrideHCID 14576944Ethyl 3-(5,6-dimethyl-3-pyridyl)propionate

Product 1

HCID 12783847Ethyl 3-(5,6-dimethyl-3-pyridyl)-2-formylpropionate

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

Reaction of ethyl 3-(5,6-dimethyl-3-pyridyl)-propionate with ethyl formate and sodium hydride in dimethoxyethane at room temperature gave ethyl 3-(5,6-dimethyl-3-pyridyl)-2-formylpropionate, m.p. 148°-9°.

Sources & evidence

ORD record
ord-facfd15b8eb94cdf940ed000bded43fe
Source dataset
uspto-grants-1980_10
Patent number
US04227000

Reaction notes

Loading…