Hydrochloric Acid → 2-Methylphenyl propanoate

HRID 904067Notes

Reaction equation

HRID 904067 reaction equation
[C:1]1([CH3:8])[C:6]([OH:7])=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:9](Cl)(=[O:12])[CH2:10][CH3:11].Cl>>[C:9]([O:7][C:6]1[C:1]([CH3:8])=[CH:2][CH:3]=[CH:4][CH:5]=1)(=[O:12])[CH2:10][CH3:11]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 335O-CresolHCID 62324Propionyl chloride

Product 1

HCID 2214362-Methylphenyl propanoateYield 98%

Procedure

Into a spherical flask equipped with a condenser, a dropping funnel and containing 2 mols of o-cresol are introduced, in 15 minutes, 2.2 mols of propionyl chloride. The mixture as obtained is heated at 110° C. for about 2 hours, until the discharge of hydrochloric acid ceases. The o-cresol propionate which is obtained is distilled under vacuum:

Workup

  1. customInto a spherical flask equipped with a condenser, a dropping funnel
  2. additionare introduced, in 15 minutes
  3. customThe mixture as obtained

Sources & evidence

ORD record
ord-369d4ee0ac27406580cadfc6b43d5bbf
Source dataset
uspto-grants-1980_10
Patent number
US04230624

Reaction notes

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