Chloroform → HCID 64554, compound

HRID 904121Notes

Reaction equation

HRID 904121 reaction equation
[N:1]1([C:7]2[N:16]=[C:15]([NH2:17])[C:14]3[C:9](=[CH:10][C:11]([O:20][CH3:21])=[C:12]([O:18][CH3:19])[CH:13]=3)[N:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.C(Cl)(Cl)Cl.[C:26]12([C:36](Cl)=[O:37])[CH2:35][CH:30]3[CH2:31][CH:32]([CH2:34][CH:28]([CH2:29]3)[CH2:27]1)[CH2:33]2>C(N(CC)CC)C>[C:26]12([C:36]([N:4]3[CH2:5][CH2:6][N:1]([C:7]4[N:16]=[C:15]([NH2:17])[C:14]5[C:9](=[CH:10][C:11]([O:20][CH3:21])=[C:12]([O:18][CH3:19])[CH:13]=5)[N:8]=4)[CH2:2][CH2:3]3)=[O:37])[CH2:33][CH:32]3[CH2:31][CH:30]([CH2:29][CH:28]([CH2:34]3)[CH2:27]1)[CH2:35]2

Participants

5

Reactant 3

HCID 6212ChloroformHCID 989151-Adamantanecarbonyl chlorideHCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline

Product 1

HCID 64554HCID 64554, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

To a mixture of 2-piperazino-4-amino-6,7-dimethoxyquinazoline (1 g), chloroform (50 ml) and triethylamine (0.42 g), was gradually added 1-adamantanecarbonyl chloride (0.83 g). The almost dissolved mixture was heated at 45°-50° C. for 2 hours. After cooling, the mixture was washed with water, dried over anhydrous sodium sulfate and evaporated under reduced pressure to give 2-{4-(1-adamantanecarbonyl)-1-piperazinyl}-4-amino-6,7-dimethoxyquinazoline, m.p. 240°-242° C.

Workup

  1. temperatureThe almost dissolved mixture was heated at 45°-50° C. for 2 hours
  2. temperatureAfter cooling
  3. washthe mixture was washed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-2e17aff07e864620bb0a15e5b56170f6
Source dataset
uspto-grants-1980_10
Patent number
US04230706

Reaction notes

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