Imidazole → HCID 54471508, compound

HRID 905057Notes

Reaction equation

HRID 905057 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.[H-].[Na+].[Cl:8][C:9]1[CH:34]=[C:33]([Cl:35])[CH:32]=[CH:31][C:10]=1[CH2:11][O:12][C@H:13]1[O:18][C@@H:17]([CH2:19]OS(C2C=CC(C)=CC=2)(=O)=O)[CH2:16][CH2:15][CH2:14]1>CN(C)C=O>[Cl:8][C:9]1[CH:34]=[C:33]([Cl:35])[CH:32]=[CH:31][C:10]=1[CH2:11][O:12][C@H:13]1[O:18][C@@H:17]([CH2:19][N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)[CH2:16][CH2:15][CH2:14]1

Participants

5

Reactant 3

HCID 795ImidazoleHCID 24758Sodium hydrideHCID 53994231HCID 53994231, compound

Product 1

HCID 54471508HCID 54471508, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

As in Example 1(b), 16 mg of imidazole, 10 mg of 55% sodium hydride and 70 mg of cis-6-(2,4-dichlorobenzyloxy)-2-tosyloxymethyltetrahydropyran were reacted in dimethylformamide, to give 37 mg of the title compound in the form of a colourless oil.

Sources & evidence

ORD record
ord-6d510b5e615f4deca004a9d2a812b55a
Source dataset
uspto-grants-1983_12
Patent number
US04421758

Reaction notes

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