反应详情

温度

80 °C

196 mg of 55% sodium hydride were added to a solution of 306 mg of imidazole in 14 ml of dimethylformamide and the mixture was stirred at 80° C. for 30 minutes. The mixture was then cooled to room temperature, after which 1.335 g of trans-6-(2,6-dichlorobenzyloxy)-2-tosyloxymethyltetrahydropyran and 450 mg of sodium iodide were added thereto; the mixture was then stirred at 80°-85° C. for 2 hours. At the end of this time, the mixture was treated and purified essentially as described in Example 1(b), to give 965 mg of the title compound in the form of a colourless oil.

1. temperatureThe mixture was then cooled to room temperature
2. stirringthe mixture was then stirred at 80°-85° C. for 2 hours
3. additionAt the end of this time, the mixture was treated
4. custompurified essentially