Isopropanol → HCID 20475754, compound

HRID 905233Notes

Reaction equation

HRID 905233 reaction equation
[CH2:1]([S:8][C:9]1[N:14]=[CH:13][C:12]([Cl:15])=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.ClC1C=CC=C(C(OO)=[O:24])C=1.CC(O)C>ClCCl>[CH2:1]([S:8]([C:9]1[N:10]=[CH:11][C:12]([Cl:15])=[CH:13][N:14]=1)=[O:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 70297m-Chloroperbenzoic acidHCID 20475729HCID 20475729, compound

Product 1

HCID 20475754HCID 20475754, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The oxidation of 2-benzylthio-5-chloropyrimidine was carried out using one molar equivalent of 85% m-chloroperbenzoic acid in dichloromethane, initially at -10° C. and then at 0° C., as described in Example 40 above; yield 88%, m.p. 92° C. (iPrOH). 1H NMR (CDCl3) δ4.30 and 4.33 (CH2), 7.23 (Ph), 8.73 (H-4, H-6).

Workup

  1. custominitially at -10° C.
  2. customat 0° C.

Sources & evidence

ORD record
ord-c92f9083ce0d490a876e6a7d259dd4d3
Source dataset
uspto-grants-1983_12
Patent number
US04423047

Reaction notes

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