Potassium Carbonate → HCID 23071570, compound

HRID 905665Notes

Reaction equation

HRID 905665 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-])=O.Br[CH2:17][CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21].C(=O)([O-])[O-].[K+].[K+]>CN1CCCC1=O>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([CH2:17][CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:12][CH2:11]2)=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 76300Ethyl 4-bromobutyrateHCID 804471-(4-Nitrophenyl)piperazine

Product 1

HCID 23071570HCID 23071570, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

1-(4-Nitrophenyl)piperazine and ethyl 4-bromobutanoate were allowed to undergo the reaction under heating in 1-methyl-2-pyrrolidone in the presence of potassium carbonate. The resulting compound was subjected to catalytic hydrogenation in the same manner as shown in Reference Example 3 to obtain ethyl 4-[4-(4-aminophenyl)-piperazin-1-yl]butanoate. F: 264.

Workup

  1. customthe reaction

Sources & evidence

ORD record
ord-ca54b7f897414b9f8517b35d53652f42
Source dataset
uspto-grants-2011_09
Patent number
US08012959B2

Reaction notes

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