Hydrochloric Acid → HCID 131729149, compound

HRID 905935Notes

Reaction equation

HRID 905935 reaction equation
C([NH:8][C@H:9]1[C@@H:15]([CH3:16])[CH2:14][CH2:13][N:12]([C:17](=[O:19])[CH3:18])[CH2:11][CH2:10]1)C1C=CC=CC=1.Cl>[Pd].CCOC(C)=O>[NH2:8][C@H:9]1[C@@H:15]([CH3:16])[CH2:14][CH2:13][N:12]([C:17](=[O:19])[CH3:18])[CH2:11][CH2:10]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 131729150HCID 131729150, compound

Product 1

HCID 131729149HCID 131729149, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

Racemic cis 1-(4-amino-5-methyl-azepan-1-yl)-ethanone was prepared in the same manner from racemic cis 1-(4-benzylamino-5-methyl-azepan-1-yl)-ethanone. In this instance, 1 atm H2 was used instead of 55 psi, Pd/C was used instead of Pd(OH)2/C, EtOAc was used instead of EtOH, and the HCl treatment was omitted.

Sources & evidence

ORD record
ord-bc9523aed4224d728a40ae13aabe13ab
Source dataset
uspto-grants-2011_09
Patent number
US08012974B2

Reaction notes

Loading…