Hydrochloric Acid → HCID 86602342, compound

HRID 906487Notes

Reaction equation

HRID 906487 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:5]=[C:6]([CH3:8])[CH:7]=1.[H-].[Na+].Cl.[CH:18](OCC)=[O:19]>>[CH3:1][C:2]1[CH:3]=[C:4]([C:9](=[CH:18][OH:19])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 8025Ethyl formateHCID 24758Sodium hydrideHCID 7021465Ethyl 3,5-dimethylphenylacetate

Product 1

HCID 86602342HCID 86602342, compound

Procedure

10 ml of ethyl 2-(3,5-dimethylphenyl)acetate are dissolved in 80 ml of ethyl formate. 5 g of 50% NaH are added portionwise and then the mixture is stirred at AT for 12 hours. The mixture is poured onto a 1N HCl solution and then extraction is carried out with AcOEt. The organic phase is evaporated to produce the expected compound, used as is in the following stage.

Workup

  1. extractionextraction
  2. customThe organic phase is evaporated

Sources & evidence

ORD record
ord-edceb4b15c364abb9a2874f3697c5492
Source dataset
uspto-grants-2011_09
Patent number
US08012991B2

Reaction notes

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