Triphenylphosphine → 2-[(SR)-1-[(3RS,4SR)-1-Benzyl-4-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-2-(tert-butyldimethyl-silanyloxy)-ethoxy]-5-chloro-pyridine

HRID 906925Notes

Reaction equation

[CH2:1]([N:8]1[CH2:12][CH:11]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]([Cl:20])[CH:14]=2)[CH:10]([CH:21]([OH:31])[CH2:22][O:23][Si:24]([C:27]([CH3:30])([CH3:29])[CH3:28])([CH3:26])[CH3:25])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Cl:51][C:52]1[CH:53]=[CH:54][C:55](O)=[N:56][CH:57]=1.C1C=CC(COC(/N=N/C(OCC2C=CC=CC=2)=O)=O)=CC=1>C1COCC1.C(OCC)(=O)C>[CH2:1]([N:8]1[CH2:12][CH:11]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]([Cl:20])[CH:14]=2)[CH:10]([CH:21]([O:31][C:55]2[CH:54]=[CH:53][C:52]([Cl:51])=[CH:57][N:56]=2)[CH2:22][O:23][Si:24]([C:27]([CH3:28])([CH3:30])[CH3:29])([CH3:26])[CH3:25])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Conditions

Temperature: 40 °C

Procedure

(SR)-1-[(3SR,4RS)-1-Benzyl-4-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-2-(tert-butyl-dimethyl-silanyloxy)-ethanol (described herein above) (13.2 mg. 0.0275 mmol) and PPh3 (PPh3 polymer bound, 3 mmol PPh3/g resin) (18 mg, 0.055 mmol) were suspended in THF (2 mL). To the mixture were added 5-chloro-pyridin-2-ol (7 mg, 0.055 mmol) and then DBAD (13 mg, 0.055 mmol). The reaction mixture was stirred at 40° C. over night. The mixture was diluted with ethyl acetate and filtered on celite and concentrated under vacuo. The residue was purified by TLC (SiO2, EtOAc/H, 1:4) yielded 7.2 mg (44%) of the title compound as a colorless oil. ES-MS m/e: 593.3 (M+H+).

Workup

filtrationfiltered on celite
concentrationconcentrated under vacuo
customThe residue was purified by TLC (SiO2, EtOAc/H, 1:4)

Sources & evidence

ORD record: ord-a4ed3545646c43f182ff398e19d24ebd
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08012998B2

Reaction notes

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