反应详情

A mixture of potassium carbonate (0.34 g), the product of Example 11 (0.1 g) and 1,4-bis(chloromethyl)benzene (0.220 g) in DMF (2 mL) was stirred at room temperature for 2.5 hours. To the reaction mixture was added pyrrolidine (0.3 mL) and stirring continued for a further 64 hours. The reaction mixture was filtered and the filtrate washed with methanol. The liquors were purified by HPLC to give the title compound as a solid (0.095 g).

1. filtrationThe reaction mixture was filtered
2. washthe filtrate washed with methanol
3. customThe liquors were purified by HPLC