Potassium Carbonate → HCID 56630813, compound

HRID 907504Notes

Reaction equation

HRID 907504 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH3:11])[CH:5]=1)=O.C(=O)([O-])[O-].[K+].[K+].Cl.[NH2:19][OH:20]>C(O)(C)C>[CH3:11][O:10][C:6]1[CH:5]=[C:4]([C:2](=[N:19][OH:20])[CH3:1])[CH:9]=[CH:8][CH:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 114603-MethoxyacetophenoneHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 56630813HCID 56630813, compoundYield 105.5%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of 50 g of 3-methoxy acetophenone in 250 ml of isopropyl alcohol charged 92 g of potassium carbonate and 46 g of hydroxylamine hydrochloride followed by heating the contents to about 60° C. and maintained for about 2 hours. The reaction mass is cooled to about 28° C., filtered the separated solid and washed with 100 ml of isopropyl alcohol. The resulting filterate was distilled under vacuum at about 55° C. to yield 58 g of 1-(3-methoxy-phenyl)-ethanone oxime.

Workup

  1. temperaturemaintained for about 2 hours
  2. temperatureThe reaction mass is cooled to about 28° C.
  3. filtrationfiltered the separated solid
  4. washwashed with 100 ml of isopropyl alcohol
  5. distillationThe resulting filterate was distilled under vacuum at about 55° C.

Sources & evidence

ORD record
ord-c2cb917c2a4147b8bfd3508aaf78fc9e
Source dataset
uspto-grants-2011_09
Patent number
US08013181B2

Reaction notes

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