Chloride → HCID 86611256, compound

HRID 908325Notes

Reaction equation

HRID 908325 reaction equation
[CH:1]1[C:10]2[C:5](=[C:6]([C:11]3[CH:12]=[C:13]4[C:18](=[CH:19][CH:20]=3)[C:17]([C:21]([OH:23])=O)=[CH:16][CH:15]=[CH:14]4)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.[Cl-:24].CN(C=O)C>C(Cl)Cl>[CH:1]1[C:10]2[C:5](=[C:6]([C:11]3[CH:12]=[C:13]4[C:18](=[CH:19][CH:20]=3)[C:17]([C:21]([Cl:24])=[O:23])=[CH:16][CH:15]=[CH:14]4)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1

Participants

5

Reactant 3

HCID 312ChlorideHCID 6228DimethylformamideHCID 58828852HCID 58828852, compound

Product 1

HCID 86611256HCID 86611256, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

6-(isoquinolin-5-yl)-1-naphthoic acid (0.123 g, 0.4 mmol) was suspended in CH2Cl2 (15 mL) and oxallyl chloride was (0.036 mL, 0.4 mmol) was added followed by a drop of DMF. The resulting mixture was stirred at room temperature overnight and the solvent was evaporated to give a solid. The solid was dried under vacuum.

Workup

  1. additionwas added
  2. customthe solvent was evaporated
  3. customto give a solid
  4. customThe solid was dried under vacuum

Sources & evidence

ORD record
ord-1b61ae75c8f94eb99daacc1196c64c57
Source dataset
uspto-grants-2011_09
Patent number
US08017601B2

Reaction notes

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