Potassium Carbonate → HCID 178513272, compound

HRID 910217Notes

Reaction equation

HRID 910217 reaction equation
Cl.[NH2:2][OH:3].C(=O)([O-])[O-].[K+].[K+].[I:10][C:11]1[CH:12]=[CH:13][C:14]2[N:15]([CH:17]=[C:18]([C:20]3[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[CH:22][CH:21]=3)[N:19]=2)[CH:16]=1>CO>[OH:3][NH:2][C:24](=[NH:25])[C:23]1[CH:22]=[CH:21][C:20]([C:18]2[N:19]=[C:14]3[CH:13]=[CH:12][C:11]([I:10])=[CH:16][N:15]3[CH:17]=2)=[CH:27][CH:26]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 67405072HCID 67405072, compound

Product 1

HCID 178513272HCID 178513272, compoundYield 73.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Hydroxylamine hydrochloride (208 mg) and potassium carbonate (415 mg) were added to a solution (10 mL) of 4-(6-iodoimidazo[1,2-a]pyridin-2-yl)benzonitrile (345 mg) in methanol, followed by refluxing for 14 hours. The mixture was left to cool, and the formed crystals were recovered through filtration. The crystals were washed with water and dried, to thereby yield the title compound (279 mg).

Workup

  1. temperatureby refluxing for 14 hours
  2. waitThe mixture was left
  3. temperatureto cool
  4. filtrationthe formed crystals were recovered through filtration
  5. washThe crystals were washed with water
  6. customdried

Sources & evidence

ORD record
ord-51f1098e9d094c048df072de84218fe9
Source dataset
uspto-grants-2011_09
Patent number
US08022075B2

Reaction notes

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