反应详情

温度

180 °C

To a microwave tube was added 2-chloro-4-(3-fluoro-4methyl-phenyl)-pyridine (30 mg, 0.14 mmol), 1-methylpiperazine (50 mg, 0.5 mmol), 2-propanol (0.6 mL) and 1 drop concentrated HCl. The resulting mixture was heated at 180° C. for 60 minutes using the microwave instrument. The resulting mixture was extracted with EtOAc. The organic layer was dried and concentrated, and the residue was purified by preparative TLC (hexanes/EtOAc) to yield the title compound as a solid.

1. extractionThe resulting mixture was extracted with EtOAc
2. customThe organic layer was dried
3. concentrationconcentrated
4. customthe residue was purified by preparative TLC (hexanes/EtOAc)