Methyl iodide → 3-Chloro-4-fluorophenyl methyl sulfide

HRID 910831Notes

Reaction equation

HRID 910831 reaction equation
IC.[Cl:3][C:4]1[CH:5]=[C:6]([SH:11])[CH:7]=[CH:8][C:9]=1[F:10].[C:12](=O)([O-])[O-].[K+].[K+]>CN(C=O)C.O>[CH3:12][S:11][C:6]1[CH:7]=[CH:8][C:9]([F:10])=[C:4]([Cl:3])[CH:5]=1

Participants

6

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 27341973-Chloro-4-fluorobenzene-1-thiol

Product 1

HCID 552207093-Chloro-4-fluorophenyl methyl sulfide

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

Iodomethane (1.15 ml) was added to a stirred mixture of 3-chloro-4-fluoro-benzenethiol (3.0 g) and potassium carbonate (2.48 g) in DMF (20 ml) and left overnight. The reaction was diluted with water and extracted with diethylether, the organics were dried and evaporated under reduced pressure, yield 4.3 g.

Workup

  1. extractionextracted with diethylether
  2. customthe organics were dried
  3. customevaporated under reduced pressure, yield 4.3 g

Sources & evidence

ORD record
ord-a3be6ec56249428aac1c9129a4c2c64c
Source dataset
uspto-grants-2011_09
Patent number
US08022248B2

Reaction notes

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