反应详情

温度

75 °C

4-(4-methoxybenzylthio)-5-bromo-N-(4-phenethylthiazol-2-yl)pyridine-2-amine (1.23 g, 2.4 mmol) was dissolved in TFA (10 mL):anisole (2 mL) (5:1). The reaction mixture was stirred at 75° C. overnight, then neutralized with solid NaHCO3, extracted with EtOAc, dried, and concentrated. The crude material was triturated in MeOH and filtered. The filtrate was further concentrated and triturated again with MeOH. The solids were combined and dried to give the desired product (0.68 g, 72% yield).

1. extractionextracted with EtOAc
2. customdried
3. concentrationconcentrated
4. customThe crude material was triturated in MeOH
5. filtrationfiltered
6. concentrationThe filtrate was further concentrated
7. customtriturated again with MeOH
8. customdried