反应详情

Slurry 3′,5′-difluoro-4′-methoxyacetophenone (1.0 g, 5.0 mmol), ammonium acetate (4.14 g, 50 mmol) and sodium cyanoborohydride (630 mg, 20 mmol) in anhydrous methanol (35 mL) and stir for 18 h at ambient temperature. Acidify with 1N aqueous HCl (5 mL), dilute, extract with ethyl ether (3×150 mL), basify aqueous with 1N aqueous NaOH, extract with DCM (3×50 mL), wash the organic extracts with brine, dry over MgSO4, filter and concentrate in vacuo. Purify by SCX chromatography to give crude the title compound as a yellow oil (380 mg).

1. additiondilute
2. extractionextract with ethyl ether (3×150 mL), basify aqueous with 1N aqueous NaOH
3. extractionextract with DCM (3×50 mL)
4. washwash the organic extracts with brine
5. dry with materialdry over MgSO4
6. filtrationfilter
7. concentrationconcentrate in vacuo
8. customPurify by SCX chromatography