Dimethylformamide → 5-[3-[(2,2,2-Trifluoroacetyl)amino]-1-propyn-1-yl]uridine

HRID 91471Notes

Reaction equation

HRID 91471 reaction equation
[CH2:26]([C:27]#[CH:28])[NH:29][C:30]([C:31]([F:32])([F:33])[F:34])=[O:35].[CH3:19][CH2:20][N:21]([CH2:22][CH3:23])[CH2:24][CH3:25].[Cu:41][I:42].[I:1][c:2]1[c:3](=[O:18])[nH:4][c:5](=[O:17])[n:6]([CH:7]2[CH:8]([OH:9])[CH:10]([OH:11])[CH:12]([CH2:13][OH:14])[O:15]2)[cH:16]1.[O:36]=[CH:37][N:38]([CH3:39])[CH3:40]>>[c:2]1([C:28]#[C:27][CH2:26][NH:29][C:30]([C:31]([F:32])([F:33])[F:34])=[O:35])[c:3](=[O:18])[nH:4][c:5](=[O:17])[n:6]([CH:7]2[CH:8]([OH:9])[CH:10]([OH:11])[CH:12]([CH2:13][OH:14])[O:15]2)[cH:16]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 2560251-[3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-iodo-pyrimidine-2,4-dioneHCID 110948052,2,2-trifluoro-N-(prop-2-yn-1-yl)acetamide

Product 1

HCID 147685505-[3-[(2,2,2-Trifluoroacetyl)amino]-1-propyn-1-yl]uridine

Sources & evidence

ORD record
ord-9352140968b74367b33e42191de84a67
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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