Water → HCID 69332723, compound

HRID 915036Notes

Reaction equation

HRID 915036 reaction equation
[C:1]([C:3]1[C:4]([N:26]=CN(C)C)=[N:5][C:6]([C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)=[C:7]([C:9]2[CH:14]=[CH:13][C:12](=[O:15])[N:11]([CH:16]([CH3:18])[CH3:17])[N:10]=2)[N:8]=1)#[N:2].O.C([O-])(O)=O.[Na+].CCOC(C)=O>Cl.O1CCOCC1>[NH2:26][C:4]1[C:3]([C:1]#[N:2])=[N:8][C:7]([C:9]2[CH:14]=[CH:13][C:12](=[O:15])[N:11]([CH:16]([CH3:18])[CH3:17])[N:10]=2)=[C:6]([C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)[N:5]=1

Participants

7

Reactant 4

HCID 962Water2×HCID 8857Ethyl AcetateHCID 516892Sodium BicarbonateHCID 69332615HCID 69332615, compound

Product 1

HCID 69332723HCID 69332723, compoundYield 69,432.602%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of N′-[3-cyano-6-(4-fluorophenyl)-5-(1-isopropyl-6-oxo-1,6-dihydro-3-pyridazinyl)-2-pyrazinyl]-N,N-dimethylimidoformamide (100 mg) in 4N HCl in dioxane (2 ml) and water (2 ml) was stirred at 25° C. for 15 hours. Water, aq. NaHCO3 and EtOAc were added to the reaction mixture. The organic layer was separated, and dried over MgSO4. The solvent was removed in vacuo. The residue was purified by silica gel column chromatography eluted with a mixture of n-hexane and EtOAc. The fractions were concentrated in vacuo to obtain 3-amino-5-(4-fluorophenyl)-6-(1-isopropyl-6-oxo-1,6-dihydro-3-pyridazinyl)-2-pyrazinecarbonitrile (60 g) as white powder.

Workup

  1. customThe organic layer was separated
  2. dry with materialdried over MgSO4
  3. customThe solvent was removed in vacuo
  4. customThe residue was purified by silica gel column chromatography
  5. washeluted with a mixture of n-hexane and EtOAc
  6. concentrationThe fractions were concentrated in vacuo

Sources & evidence

ORD record
ord-a61c7ecc0db74084b634ddc219fade7e
Source dataset
uspto-grants-2007_09
Patent number
US07265120B2

Reaction notes

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