反应详情

温度

27.5 °C

In the presence of copper(I) iodide (25 mg) and dichlorobis(triphenylphosphine)palladium(II) (91 mg), triethylamine (0.397 ml) was dropwise added to a mixture of 6-(5-amino-6-bromo-3-phenyl-2-pyrazinyl)-2-isopropyl-3(2H)-pyridazinone (1.00 g) and ethynyl(trimethyl)silane (0.716 ml) in 1,2-dichloroethane (20 ml) under ice-cooling. The mixture was stirred at same temperature for one hour and at 25-30° C. for 18 hours. After addition of water, an organic layer was collected, washed with sat. aq. sodium chloride, dried over MgSO4 and concentrated under reduced pressure to give a residue. The residue was purified by column chromatography on silica gel eluting with a mixture of n-hexane and EtOAc (80:20 v/v) to give a solid. The solid was crystallized from a mixture of acetone and n-hexane to give 6-{5-amino-3-phenyl-6-[(trimethylsilyl)ethynyl]-2-pyrazinyl}-2-isopropyl-3(2H)-pyridazinone (431 mg).

1. temperaturecooling
2. customan organic layer was collected
3. washwashed with sat. aq. sodium chloride
4. dry with materialdried over MgSO4
5. concentrationconcentrated under reduced pressure
6. customto give a residue
7. customThe residue was purified by column chromatography on silica gel eluting with a mixture of n-hexane and EtOAc (80:20 v/v)
8. customto give a solid
9. customThe solid was crystallized from a mixture of acetone and n-hexane