反应详情

In the presence of copper(I) iodide (5 mg) and dichlorobis(triphenylphosphine)palladium(II) (18 mg), triethylamine (0.0794 ml) was dropwise added to a mixture of 6-(5-amino-6-bromo-3-phenyl-2-pyrazinyl)-2-isopropyl-3(2H)-pyridazinone (200 mg) and ethynylbenzene (0.0626 ml) in 1,2-dichloroethane (2 ml) at 60° C. The mixture was refluxed for 2 hours. The mixture was cooled to give a precipitate. The precipitate was collected by filtration and suspended in MeOH to give 6-[5-amino-3-phenyl-6-(phenylethynyl)-2-pyrazinyl]-2-isopropyl-3(2H)-pyridazinone (104 mg).

1. temperatureThe mixture was refluxed for 2 hours
2. temperatureThe mixture was cooled
3. customto give a precipitate
4. filtrationThe precipitate was collected by filtration