反应详情

4-(3,4-Dichlorophenoxy)piperidine (4.15 g) was dissolved in acetone (80 ml). Potassium carbonate (2.42 g), sodium iodide (0.49 g) and then methyl 4-bromobutyrate (1.95 ml) were added and the mixture was stirred for 42 h. The solvent, was evaporated and the residue was partitioned between water and ethyl acetate. The aqueous phase was extracted with ethyl acetate. The organic phases were dried (MgSO4), filtered and evaporated and the residue was chromatographed eluting with ethyl acetate: triethylamine (99:1) to give the subtitle compound (4.52 g).

1. customThe solvent, was evaporated
2. customthe residue was partitioned between water and ethyl acetate
3. extractionThe aqueous phase was extracted with ethyl acetate
4. dry with materialThe organic phases were dried (MgSO4)
5. filtrationfiltered
6. customevaporated
7. customthe residue was chromatographed
8. washeluting with ethyl acetate: triethylamine (99:1)