Methanesulfonic Acid → HCID 136342084, compound

HRID 915924Notes

Reaction equation

HRID 915924 reaction equation
[CH:1]1([C:7]2[C:15]3[C:14](=[O:16])[NH:13][C:12]([C:17]4[CH:22]=[CH:21][C:20]([N:23]5[CH2:28][CH2:27][N:26]([CH3:29])[CH2:25][CH2:24]5)=[CH:19][C:18]=4[O:30][CH3:31])=[N:11][C:10]=3[N:9]([CH3:32])[N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:33][S:34]([OH:37])(=[O:36])=[O:35]>O1CCCC1>[CH3:33][S:34]([OH:37])(=[O:36])=[O:35].[CH:1]1([C:7]2[C:15]3[C:14](=[O:16])[NH:13][C:12]([C:17]4[CH:22]=[CH:21][C:20]([N:23]5[CH2:28][CH2:27][N:26]([CH3:29])[CH2:25][CH2:24]5)=[CH:19][C:18]=4[O:30][CH3:31])=[N:11][C:10]=3[N:9]([CH3:32])[N:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 135444737HCID 135444737, compound

Product 1

HCID 136342084HCID 136342084, compoundYield 66.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a 3 ml tetrahydrofuran/4 ml dioxane mixed solution of 450 mg (1.03 mmol) of the compound obtained in Example 27, 68.6 μl (1.05 mmol) of methanesulfonic acid was added, and precipitated solids were collected by filtration. The solids were purified by recrystallization (ethanol) to obtain 364 mg (66%) of the captioned compound.

Workup

  1. customprecipitated solids
  2. filtrationwere collected by filtration
  3. customThe solids were purified by recrystallization (ethanol)

Sources & evidence

ORD record
ord-570c8f6ca3fe43f2a78696f16ef86c4b
Source dataset
uspto-grants-2007_09
Patent number
US07268128B2

Reaction notes

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