Hydrochloric Acid → HCID 178479266, compound

HRID 916050Notes

Reaction equation

HRID 916050 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@@H:11]([N:14]2[CH:18]=[C:17]([C:19]([N:21]3[CH2:25][CH2:24][CH2:23][CH2:22]3)=[O:20])[N:16]=[N:15]2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:27]>CCOC(C)=O.CO>[ClH:27].[NH2:7][C@@H:8]1[CH2:9][CH2:10][C@H:11]([N:14]2[CH:18]=[C:17]([C:19]([N:21]3[CH2:25][CH2:24][CH2:23][CH2:22]3)=[O:20])[N:16]=[N:15]2)[CH2:12][CH2:13]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178453980HCID 178453980, compound

Product 1

HCID 178479266HCID 178479266, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

{cis-4-[4-(Pyrrolidine-1-carbonyl)-[1,2,3]triazol-1-yl]-cyclohexyl}-carbamic acid tert-butyl ester (406 mg) was stirred 1 h in a mixture of 4.6 M HCl in EtOAc (3.6 ml) and MeOH (0.84 ml). The solvent was evaporated to yield the product (335 mg, quant.) as white foam after drying on the high vacuum. MS 264.3 (100, [M+H]+).

Workup

  1. customThe solvent was evaporated
  2. customto yield the product (335 mg, quant.) as white foam
  3. customafter drying on the high vacuum

Sources & evidence

ORD record
ord-2d7b70450baf45e48253b642f2ad70b2
Source dataset
uspto-grants-2007_09
Patent number
US07268154B2

Reaction notes

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