反应详情

温度

110 °C

To a round bottom flask with DMF (5 mL), was added 7-Cyclopentyl-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine, CuI, N-methylmorphline and (3-Mercapto-phenyl)-carbamic acid tert-butyl ester. The reaction was heated at 110° C. overnight. After cooling to room temperature, the reaction mixture was extracted with EtOAc (80 mL) and saturated sodium bicarbonate solution (60 ml). The organic layer was washed with water, brine, dried over sodium sulfate and concentrated. Purification through flash column afforded the product as a light yellow solid (108 mg, 85%). MS: 426.1 (MH+); HPLC Rf: 6.332 min.; HPLC purity: 96%.

1. temperatureAfter cooling to room temperature
2. extractionthe reaction mixture was extracted with EtOAc (80 mL) and saturated sodium bicarbonate solution (60 ml)
3. washThe organic layer was washed with water, brine
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated
6. customPurification through flash column