Dichloromethane → HCID 87824249, compound

HRID 916954Notes

Reaction equation

HRID 916954 reaction equation
C(Cl)[Cl:2].[Cl:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:12]([C:29]3[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][C:30]=3[Cl:36])=[N:13][C:14]([O:20][C:21]3[CH:26]=[CH:25][C:24]([F:27])=[C:23]([F:28])[CH:22]=3)=[C:15]([CH:19]=2)[C:16]([OH:18])=O)=[CH:7][CH:6]=1.C(Cl)(=O)C(Cl)=O>CN(C=O)C.C1(C)C=CC=CC=1>[Cl:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[C:12]([C:29]3[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][C:30]=3[Cl:36])=[N:13][C:14]([O:20][C:21]3[CH:26]=[CH:25][C:24]([F:27])=[C:23]([F:28])[CH:22]=3)=[C:15]([CH:19]=2)[C:16]([Cl:2])=[O:18])=[CH:9][CH:10]=1

Participants

6

Reactant 3

HCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 58961580HCID 58961580, compound

Product 1

HCID 87824249HCID 87824249, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 1140TolueneSolvent

Procedure

To a dried round bottom flask was added methylene chloride (2 mL), the product of Example 86 (0.110 g; 0.217 mmol), oxalyl chloride (0.02 mL, 0.217 mmol), and DMF (1 drop; cat.). The reaction mixture was stirred for 1.5 hours at room temperature. Toluene (1 mL) was added to the reaction mixture and the volatiles were removed in vacuo.

Workup

  1. customthe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-767fb47ef49e469f93dec35b577e580f
Source dataset
uspto-grants-2007_09
Patent number
US07271266B2

Reaction notes

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