Dimethylformamide dimethyl acetal → HCID 69417527, compound

HRID 916962Notes

Reaction equation

HRID 916962 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:18])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1.CO[CH:21](OC)[N:22]([CH3:24])[CH3:23]>CN(C=O)C>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:18])[C:10]([C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)=[CH:21][N:22]([CH3:24])[CH3:23]

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 61078770HCID 61078770, compound

Product 1

HCID 69417527HCID 69417527, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
75 °C

Procedure

To a solution of the ketone product from Step A (6.0 g; 21.3 mmol) in DMF (100 mL) in a dried round bottom flask was added N,N-dimethylformamide dimethyl acetal (11.3 mL; 85.1 mmol) under a N2 atmosphere, and the reaction was stirred at 75° C. for 16 hours. Most of the volatiles were removed in vacuo to afford the crude product as a oil which was used in the next step without further purification.

Workup

  1. customMost of the volatiles were removed in vacuo

Sources & evidence

ORD record
ord-51da51642ea44d4c8e37aa23019ee63e
Source dataset
uspto-grants-2007_09
Patent number
US07271266B2

Reaction notes

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