4-Methylmorpholine → HCID 86597252, compound

HRID 917423Notes

Reaction equation

HRID 917423 reaction equation
[CH3:1][O:2][CH2:3][C:4]([OH:6])=O.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CN1CCOCC1.[CH3:38][O:39][C:40]1[C:41]2[N:54]=[C:53]([NH2:55])[S:52][C:42]=2[C:43]([N:46]2[CH2:51][CH2:50][O:49][CH2:48][CH2:47]2)=[N:44][CH:45]=1>C1COCC1>[CH3:1][O:2][CH2:3][C:4]([NH:55][C:53]1[S:52][C:42]2[C:43]([N:46]3[CH2:51][CH2:50][O:49][CH2:48][CH2:47]3)=[N:44][CH:45]=[C:40]([O:39][CH3:38])[C:41]=2[N:54]=1)=[O:6]

Participants

6

Reactant 4

HCID 79724-MethylmorpholineHCID 12251Methoxyacetic AcidHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 860385537-Methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-ylamine

Product 1

HCID 86597252HCID 86597252, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

From methoxyacetic acid, HATU and N-methylmorpholine in THF, then treatment with 7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-ylamine. ES-MS m/e (%): 339 (M+H+, 100).

Sources & evidence

ORD record
ord-9334bfd1a9a947b5b57043c1bc876d8d
Source dataset
uspto-grants-2007_09
Patent number
US07273865B2

Reaction notes

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