Morpholine → HCID 86597273, compound

HRID 917452Notes

Reaction equation

HRID 917452 reaction equation
[CH3:1][O:2][C:3]1[C:4]2[N:17]=[C:16]([NH2:18])[S:15][C:5]=2[C:6]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[N:7][CH:8]=1.Cl[CH2:20][C:21]1[CH:29]=[CH:28][C:24]([C:25](Cl)=[O:26])=[CH:23][CH:22]=1.C(N(C(C)C)C(C)C)C.[NH:39]1[CH2:44][CH2:43][O:42][CH2:41][CH2:40]1>ClCCCl.C1COCC1>[CH3:1][O:2][C:3]1[C:4]2[N:17]=[C:16]([NH:18][C:25](=[O:26])[C:24]3[CH:28]=[CH:29][C:21]([CH2:20][N:39]4[CH2:44][CH2:43][O:42][CH2:41][CH2:40]4)=[CH:22][CH:23]=3)[S:15][C:5]=2[C:6]([N:9]2[CH2:10][CH2:11][O:12][CH2:13][CH2:14]2)=[N:7][CH:8]=1

Participants

7

Reactant 4

HCID 8083MorpholineHCID 701364-(Chloromethyl)benzoyl chlorideHCID 81531DiisopropylethylamineHCID 860385537-Methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-ylamine

Product 1

HCID 86597273HCID 86597273, compound

Reagents, catalysts & solvents 2

HCID 111,2-DichloroethaneSolventHCID 8028TetrahydrofuranSolvent

Procedure

From 7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-ylamine with 4-(chloromethyl)benzoyl chloride and N-ethyldiisopropylamine in 1,2-dichloroethane and THF; then subsequent treatment with morpholine. ES-MS m/e (%): 470 (M+H+, 100).

Sources & evidence

ORD record
ord-201325f0fab3476a8719d736c2b44030
Source dataset
uspto-grants-2007_09
Patent number
US07273865B2

Reaction notes

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