反应详情

A 1 g. portion of the product of Example 2 was suspended in 40 ml. of dimethylformamide, the suspension was cooled under nitrogen to 0°-5°C., and an 0.3 g. portion of 50 percent NaH in oil was added. The reaction mixture was stirred for 30 minutes, and 3 ml. of ethyl iodide was added. The mixture was stirred at 0°-5°C. for 24 hours, and the mixture was then filtered to separate the precipitated product. The dried product was 1.0 g. of 1-ethyl-3,5-diphenyl-4(1H)-pyridazinone, m.p. 124°-25°C., which was identified by nuclear magnetic resonance analysis, infrared analysis, and mass spectrometry.

1. stirringThe mixture was stirred at 0°-5°C. for 24 hours
2. filtrationthe mixture was then filtered
3. customto separate the precipitated product