Cyanuric chloride → HCID 86668818, compound

HRID 921434Notes

Reaction equation

HRID 921434 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([P:8](=[O:11])([CH3:10])[CH3:9])=[CH:4][CH:3]=1.[Cl:12][C:13]1[N:18]=[C:17](Cl)[N:16]=[C:15]([Cl:20])[N:14]=1>CN(C)C=O.C(N(C(C)C)CC)(C)C>[Cl:12][C:13]1[N:14]=[C:15]([Cl:20])[N:16]=[C:17]([NH:1][C:2]2[CH:3]=[CH:4][C:5]([P:8]([CH3:9])([CH3:10])=[O:11])=[CH:6][CH:7]=2)[N:18]=1

Participants

5

Reactant 2

HCID 7954Cyanuric chlorideHCID 206345534-(Dimethylphosphoryl)aniline

Product 1

HCID 86668818HCID 86668818, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 81531DiisopropylethylamineSolvent

Conditions

Temperature
0 °C

Procedure

A suspension of 4-amino-dimethylphenylphosphine oxide (3.7 g, 2.2 mmol) in 15 mL of N,N-Dimethylformamide and 3.6 mL of Diisopropylethylamine is cooled to 0° C. 2,4,6-trichloro-1,3,5-triazine (2.6 mmol) is added in four portions over 5 minutes. The reaction mixture is warmed up to room temperature and stirred until formation of the desired compound. The reaction mixture is filtered and purified by prep-HPLC.

Workup

  1. temperatureThe reaction mixture is warmed up to room temperature

Sources & evidence

ORD record
ord-1235cf4cf26f4d628bb09b869b3b548e
Source dataset
uspto-grants-2016_03
Patent number
US09273077B2

Reaction notes

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